Geant4 is a powerful, open-source Monte Carlo simulation toolkit widely used in medical physics, supporting applications in treatment verification, imaging dosimetry, nuclear medicine, radiation protection, and radiobiology. This workshop highlights Geant4’s capabilities and showcases realistic applications in X-ray radiotherapy, hadron therapy, imaging, shielding, and radiobiology using platforms such as GATE, TOPAS, and GAMOS. Participants will also gain insights from developers and experienced users.