Geant4 is an open-source Monte Carlo radiation physics simulation code, extensively used in medical physics, including verification of radiotherapy treatment planning systems, and the design of equipment for radiotherapy and nuclear medicine. It is also used in medical imaging for dosimetry, to improve detectors and reconstruction algorithms, and for radiation protection assessments. Geant4 can be used in stand-alone applications or via software tools like GAMOS, GATE, PTSim, and TOPAS. This workshop will provide an overview of Geant4 capability of interest for medical applications, then, realistic applications of the Toolkit will be illustrated in X-ray radiotherapy, hadron therapy, imaging, nuclear medicine, radiation shielding and radiobiology.